Drug Index

Sucralfate

 
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Mechanism :

Sucralfate’s ability to accelerate healing of duodenal ulcers remains to be fully defined, it is known that it exerts its effect through a local, rather than systemic, action. Sucralfate forms an ulcer-adherent complex with proteinaceous exudate at the ulcer site.


Indication :

• Stress ulcer prophylaxis

• Esophageal and gastric variceal bleeding prophylaxis

• Oesophagitis

• Upper Gl bleed of unknown cause


Contraindications :

There are no known contraindications to the use of sucralfate.


Dosing :

The safety and efficacy in children under 14 years of age is not established.

10-20 mg/kg/PO 1 hour before meal (Max: 80 mg/kg/day PO or alternatively, up to 2000 mg/day PO).


Adverse Effect :

Constipation, nausea, gastric discomfort, indigestion, flatulence, dry mouth, pruritus, rash, dizziness, insomnia, sleepiness, vertigo, back pain, headache. Hypersensitivity reactions, including urticaria (hives), angioedema, respiratory difficulty.


Interaction :

Potassium Acid Phosphate/Potassium Phosphate: Combination may decrease phosphate efficacy.


07/18/2019 02:44:25 Sucralfate
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