Drug Index


Synonyms :

Beractant, Calfactant, Lucinactant, Poractant Alfa

Mechanism :

Endogenous pulmonary surfactant lowers surface tension on alveolar surfaces during respiration and stabilizes the alveoli against collapse at resting transpulmonary pressures. Deficiency of pulmonary surfactant causes Respiratory Distress Syndrome (RDS) in premature infants. Natural surfactant, a combination of lipids and apoproteins, exhibits not only surface tension-reducing properties (conferred by the lipids), but also rapid spreading and adsorption (conferred by the apoproteins.

Indication :

  • Prevention and treatment of respiratory distress syndrome in newborns

Contraindications :

Stabilise the baby before administration. Be prepared to make early adjustments to ventilation to take account of possible rapid improvement in lung compliance following surfactant administration.

Dosing :

Poractant alfa:
1.25-2.5 ml/kg within 15 mins of birth, for prevention.
Treatment: 2.5 ml/kg birth weight intratracheal, then, 1.25 ml/kg every 12 hours, two times as needed. Max: 5 ml/kg total.
4 ml/kg (1 ml = 100 mg) within 15 mins of birth, intratracheal for prevention.
Treatment: 4 ml/kg within 8 hours of birth intratracheal. May administer 4 doses during 48 hours.
3 ml/kg intratracheal every 12 hours for upto 3 doses.
5.8 ml/kg intratracheal. Divide dose into 4 aliquots to administer. May administer 4 doses during 48 hours.

Adverse Effect :

Transient bradycardia is most frequently seen, also endotracheal tube reflux, pallor, vasoconstriction, hypotension, endotracheal tube blockage, hypertension, hypocarbia, hypercarbia, and apnea have been reported.

Interaction :

No known interactions found.

Hepatic Dose :

No dosage adjustments are recommended.
02/20/2021 09:31:52 Surfactants
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0