Drug Index

Tafenoquine

 
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Mechanism :

Tafenoquine is an 8-aminoquinoline antimalarial drug active against pre-erythrocytic (liver) forms (including hypnozoite [dormant stage]) and erythrocytic (asexual) forms, as well as gametocytes, of Plasmodium species, including P. falciparum and P. vivax.


Indication :

• Malaria, chemoprophylaxis

• Prevention of relapse of Plasmodium vivax


Contraindications :

Hypersensitivity to tafenoquine, other 8-aminoquinolines, or any component of the formulation; G6PD deficiency or unknown G6PD status; patients with a history of psychotic disorders or current psychotic symptoms.


Dosing :

>16 years of age:

Chemoprophylaxis:

200 mg once daily for 3 days prior to travel to a malarious area and then 200 mg once weekly while in the endemic area. Continue for 1 week after return.

Prevention of relapse of P. vivax:

Oral: 300 mg as a single dose on the first or second day of the appropriate antimalarial therapy.


Adverse Effect :

Hypersensitivity to tafenoquine, other 8-aminoquinolines, or any component of the formulation; G6PD deficiency or unknown G6PD status; patients with a history of psychotic disorders or current psychotic symptoms.

Headache, diarrhea, methemoglobinemia, back pain, epithelial keratopathy, sleep disorder, depressed mood, insomnia, nausea, motion sickness.

07/21/2019 21:45:19 Tafenoquine
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