Drug Index

Tecovirimat

 
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Mechanism :

Tecovirimat inhibits the activity of the orthopoxvirus VP37 protein and blocks its interaction with cellular Rab9 GTPase and TIP47, preventing formation of egress-competent enveloped virions.


Indication :

• Smallpox


Contraindications :

No contraindications.


Dosing :

13 to <25 kg: 200 mg twice daily orally for 14 days.

25 to <40 kg: 400 mg twice daily orally for 14 days.

≥40 kg: 600 mg twice daily orally for 14 days.


Adverse Effect :

Headache, tachycardia, abnormal EEG, depression, irritability, cheilosis, facial erythema, increased thirst, nausea, abdominal pain, arthralgia.


Interaction :

Midazolam: Tecovirimat may decrease the serum concentration of Midazolam.
Repaglinide: Tecovirimat may increase the serum concentration of Repaglinide.


07/17/2019 20:39:01 Tecovirimat
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