Drug Index

Tenofovir Disoproxil Fumarate

Synonyms :

TDF, Tenofovir DF

Indication :

  • HIV infection
  • Chronic Hepatitis B

Dosing :

HIV Infection:
2-12 years: 8 mg/kg orally once a day, Maximum: 300 mg/day.
>12 years: 300 mg OD.
Chronic Hepatitis B:
≥12 years, ≥35 kg: 300 mg orally once a day.
The optimum duration of treatment is not known.

Adverse Effect :

Asthenia, diarrhea, nausea, pain, anorexia, depression, myalgia, peripheral neuropathy, dyspepsia, rash, headache, vomiting, flatulence, abdominal pain, neutropenia, increased transaminases, new onset or worsening renal impairment, lactic acidosis, decreased bone mineral density.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50245 mg every 48 hours
10-30245 mg every 72–96 hours
<10245 mg every 7 days

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDDialysed. Dose as in GFR=10– 30 mL/min

Hepatic Dose :

No dose adjustment recommended. Use cautiously in patients with liver disease due to risk of hepatotoxicity.
02/13/2024 15:01:44 Tenofovir Disoproxil Fumarate
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