Drug Index


Mechanism :

Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is an inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin is released following the enzymatic cleavage of 3 glycyl moieties.

Indication :

  • Acute oesophageal variceal haemorrhage
  • Refractory septic shock

Contraindications :

Hypersensitivity, vascular disease esp coronary artery disease, chronic nephritis (until normal blood-nitrogen concentration attained). Pregnancy.

Dosing :

The initial recommended dose is 2 mg IV, then 1 or 2 mg 4-6 hourly until bleeding is controlled, up to 72 hour.

Adverse Effect :

Abdominal cramps, cardiac arrhythmias, headache, transient blanching, increased arterial pressure. Potentially Fatal: myocardial infarction, cardiac failure.

Interaction :

Drug Interactions Not Available.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function. Use with caution
<10Dose as in normal renal function. Use with caution

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR<10 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
02/22/2024 18:44:11 Terlipressin
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