Drug Index

Testosterone Esters

Synonyms :

Testosterone Cypionate, Testosterone Enanthate

Mechanism :

Endogenous androgens are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement; vocal cord thickening; alterations in body musculature; and fat distribution.

Indication :

  • Hypogonadism in males (primary, Hypogonadotropic)
  • Delayed puberty in males

Contraindications :

Contraindicated in known hypersensitivity, in men with carcinomas of the breast, with known or suspected carcinomas of the prostate, in women who are or may become pregnant, androgens cause virilization of the external genitalia of the female fetus. The degree of masculinization is related to the amount of drug given and the age of the fetus and is most likely to occur in the female fetus when the drugs are given in the first trimester.

Dosing :

12 years and above in males.
Hypogonadism in males:
Testosterone cypionate:
50-400 mg every 2-4 weeks intramuscular.
Testosterone enanthate:
50-400 mg every 2-4 weeks intramuscular.
Delayed puberty in males:
>12 years:
50-200 mg intramuscular every 2-4 weeks for 4-6 months.

Adverse Effect :

In females: Amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, virilisation, including deepening of the voice and clitoral enlargement.

In males: Gynecomastia, and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages. Hirsutism, male pattern baldness and acne.

Interaction :

Acenocoumarol: The androgen, Testosterone, may increase the anticoagulant effect of the Vitamin K antagonist, Acenocoumarol. Monitor for changes in the therapeutic effect of Acenocoumarol if Testosterone is initiated, discontinued or dose changed.
Anisindione: The androgen may increase the anticoagulant effect of anisindione.
Cyclosporine: The androgen, Testosterone, may increase the hepatotoxicity of Cyclosporine. Testosterone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
Dicoumarol: The androgen may increase the anticoagulant effect of dicumarol.
Docetaxel: Testosterone may increase the serum levels and toxicity of docetaxel.
Warfarin: Testosterone may increase the serum concentration and anticoagulant effect of warfarin. Monitor for changes in prothrombin time and therapeutic effects of warfarin if testosterone is initiated, discontinued or dose changed.

Hepatic Dose :

Use with caution; may enhance edema formation. Testosterone cypionate is contraindicated in serious hepatic disease.
01/20/2024 14:19:31 Testosterone Esters
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