Drug Index



Mechanism :

Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors.

Indication :

• Urinary Urgency

• Urinary incontinence

• Urinary frequency

Contraindications :

Contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma, and in patients who have demonstrated hypersensitivity to the drug or its ingredients. Caution in liver and renal impairment.

Dosing :

<35 kg: 2 mg/day PO once daily.

>35 kg: 4 mg/day PO once daily.

Usually effective within 4 weeks.

Adverse Effect :

Frequently seen adverse reactions include constipation, dyspepsia, nausea, abdominal discomfort. Dry mouth, blurred vision, drowsiness, paraesthesia, dry skin, facial flushing, headache and dizziness may also occur.

Interaction :

Ketoconazole: An inhibitor of the drug metabolizing enzyme CYP3A4, significantly increased plasma concentrations of tolterodine when coadministered to subjects who were poor metabolizers.
Macrolide antibiotics: Avoid use with macrolide antibiotics.

03/14/2020 08:33:50 Tolterodine
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