Drug Index

Trimethobenzamide

 
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Mechanism :

Acts centrally to inhibit the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting centre.


Indication :

• Nausea

• Vomiting


Contraindications :

Hypersensitivity to trimethobenzamide or any component of the formulation; injection contraindicated in children.


Dosing :

20 mg/kg/day PO divided every 6-8 hours.


Adverse Effect :

Dizziness, Parkinson-like symptoms, sedation, headache, hypersensitivity reactions, irritation at injection site.


Interaction :

Glycopyrronium (Topical): May enhance the anticholinergic effect of Anticholinergic Agents.
Ipratropium (Oral Inhalation), Tiotropium: May enhance the anticholinergic effect of Anticholinergic Agents.



Hepatic Dose :

Dose adjustment guidelines are not available. Use of this drug in patients of hepatic impairment should be avoided as it may cause hepatotoxicity.
05/30/2020 04:41:32 Trimethobenzamide
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