Trimethobenzamide
Mechanism :
Acts centrally to inhibit the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting centre.
Indication :
Contraindications :
Hypersensitivity to trimethobenzamide or any component of the formulation; injection contraindicated in children.
Dosing :
20 mg/kg/day PO divided every 6-8 hours.
Adverse Effect :
Dizziness, Parkinson-like symptoms, sedation, headache, hypersensitivity reactions, irritation at injection site.
Interaction :
Glycopyrronium (Topical): May enhance the anticholinergic effect of Anticholinergic Agents.
Ipratropium (Oral Inhalation), Tiotropium: May enhance the anticholinergic effect of Anticholinergic Agents.
Hepatic Dose :
Dose adjustment guidelines are not available. Use of this drug in patients of hepatic impairment should be avoided as it may cause hepatotoxicity.