Drug Index

Tromethamine

 
print
Synonym :

THAM

Mechanism :

Acts as a proton acceptor, which combines with hydrogen ions, liberating bicarbonate buffer, to correct acidosis. Also, an osmotic diuretic.


Indication :

• Correction of metabolic acidosis associated with cardiac bypass surgery or cardiac arrest.

• To correct excess acidity of stored blood that is preserved with acid citrate dextrose.

• Infants needing alkalinisation after receiving maximum sodium bicarbonate.


Contraindications :

Hypersensitivity to tromethamine or any component of the formulation; Uremia or anuria; Chronic respiratory acidosis (neonates); Salicylate intoxication (neonates).


Dosing :

Dose depends on buffer base deficit; when deficit is known: Tromethamine (ML of 0.3 molar [M] solution) = body weight (kg) x base deficit (MEq/L) x 1.1


Adverse Effect :

Alkalosis, localized phlebitis, venospasm, hyperkalemia, hypervolemia, hypoglycaemia, hepatic necrosis, apnea, pulmonary edema, respiratory depression.


Interaction :

Alpha-/Beta-Agonists (Indirect-Acting): Alkalinizing Agents may increase the serum concentration of Alpha-/Beta-Agonists.
Amphetamines: Alkalinizing Agents may decrease the excretion of Amphetamines.


08/08/2019 17:33:54 Tromethamine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0