Drug Index


Synonym :


Mechanism :

Acts as a proton acceptor, which combines with hydrogen ions, liberating bicarbonate buffer, to correct acidosis. Also, an osmotic diuretic.

Indication :

  • Correction of metabolic acidosis associated with cardiac bypass surgery or cardiac arrest.
  • To correct excess acidity of stored blood that is preserved with acid citrate dextrose.
  • Infants needing alkalinisation after receiving maximum sodium bicarbonate.

Contraindications :

Hypersensitivity to tromethamine or any component of the formulation; Uremia or anuria; Chronic respiratory acidosis (neonates); Salicylate intoxication (neonates).

Dosing :

Dose depends on buffer base deficit; when deficit is known: Tromethamine (ML of 0.3 molar [M] solution) = body weight (kg) x base deficit (MEq/L) x 1.1

Adverse Effect :

Alkalosis, localized phlebitis, venospasm, hyperkalemia, hypervolemia, hypoglycaemia, hepatic necrosis, apnea, pulmonary edema, respiratory depression.

Interaction :

Alpha-/Beta-Agonists (Indirect-Acting): Alkalinizing Agents may increase the serum concentration of Alpha-/Beta-Agonists.
Amphetamines: Alkalinizing Agents may decrease the excretion of Amphetamines.

Hepatic Dose :

No dose adjustment recommended.
01/19/2024 02:28:47 Tromethamine
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