Drug Index

Yellow Fever Vaccine

Mechanism :

Yellow Fever Vaccine, for subcutaneous use, is prepared by culturing the 17D-204 strain of yellow fever virus in living avian leukosis virus-free chicken embryos.

Indication :

  • Yellow fever prophylaxis to children >9 months for travellers to endemic areas

Contraindications :

Contraindicated in anyone with a history of acute hypersensitivity reaction to any components (including gelatin), with a history of acute hypersensitivity to eggs or egg products, infants less than 9 months of age, because of the risk of encephalitis, and travel of such persons to rural areas in yellow fever endemic zones or to countries experiencing an epidemic should be postponed or avoided, whenever possible. Exposure to yellow fever vaccine, which is a live virus vaccine, poses a risk of encephalitis or other serious adverse events to patients with illnesses that commonly result in immunosuppression (e.g., acquired immunodeficiency syndrome or other manifestations of human immunodeficiency virus (HIV) infection, leukemia, lymphoma, thymic disease, generalized malignancy), or patients whose immunologic responses are suppressed by drug therapy (e.g., corticosteroids, alkylating drugs, or antimetabolites) or radiation.

Dosing :

>9 months: SC 0.5 ml >10 days before travel.
Booster dose may be given for high risk, after 10 years.

Adverse Effect :

Adverse reactions include mild headaches, chills, myalgia, low-grade fevers. Local reactions including edema, hypersensitivity, pain or mass at the injection site have also been reported following yellow fever vaccine administration. Immediate hypersensitivity reactions, characterized by rash, urticaria, and/or asthma, are uncommon and occur principally among persons with histories of egg allergy.

Interaction :

As it is a live vaccine it may be given at the same time as other live vaccines or after a minimum interval of 3 weeks. It should not be given within a period of 3 weeks before and 3 months after human immunoglobulin and blood or plasma transfusions. The vaccine should not be given to children <1-year-old, as maternal antibodies may interfere with the response. A tuberculin test should ideally be postponed until 4 weeks have elapsed since immunization.

Hepatic Dose :

No dose adjustment recommended.
02/21/2024 22:08:50 Yellow Fever Vaccine
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