Optimal pathogen - directed therapy using the maldi tof in pediatrics

ORIGINAL ARTICLE

Optimal Pathogen - Directed Therapy using the MALDI TOF in Pediatrics

Kenice Ferguson-Paul¹, Xinhua Yu², Bindiya Bagga³, Sandra R Arnold³.

¹Department of Pediatrics,Division of Infectious Diseases, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA and Le Bonheur Children’s Hospital, Memphis, Tennessee, USA and Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA,
²Department of Epidemiology, University of Memphis, Memphis, Tennessee, USA,
³Department of Pediatrics,Division of Infectious Diseases, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA and Le Bonheur Children’s Hospital, Memphis, Tennessee, USA.

Show affiliations

Abstract
Background: Our objective was to determine the effect of the MALDI TOF on time to optimal antimicrobial therapy in bloodstream infections (BSI) compared to conventional methods.
Methods: We reviewed all positive blood cultures from February 2012-2014. The control group (CG) had pathogen identification using conventional methods and the intervention group (IG) with MALDI-TOF.
Results: There were 199 cultures (CG, n=121, IG, n=78). The median time to species identification (hours) for the CG was 48, interquartile range (IQR) 37-57 vs. IG=17, IQR 14-23 (median difference 31, 95% Confidence Interval (CI) -38 to -25). Median time to optimal therapy (hours) for the CG was 28, IQR 2-64 vs. IG= 14.5, IQR 3-55 (median difference -13.5, 95% CI -31-13). By Cox regression MALDI TOF was not associated with reduced time to optimal therapy (hazard ratio (HR) 1.2, p=0.64).
Conclusions: Species level identification is faster with MALDI TOF in BSI but does not allow for faster time to optimal antimicrobials.

READ FULL TEXT

Home

Articles & Issues

About

Contribute

Home

Partner Sites