ISSN - 0973-0958
Ten Days Versus Fourteen Days Antibiotic Therapy in Culture Proven Neonatal Sepsis: Single Center Egyptian Experience
Elsayed Ibrahim Salama, Hassan Said Badr, Mostafa Hamed Mohammed.
Department of Pediatrics, National Liver Institute and Faculty of Medicine, Menoufyia University, Egypt.
 
Abstract
Aim: To compare the efficacy of a 10 days course versus the conventional 14 days course of antibiotic therapy in neonatal sepsis proven by blood culture.
Methods: The study was done in the neonatal intensive care unit (NICU) in 30 neonates with culture positive neonatal sepsis. They were subdivided into 2 groups: 15 cases for 10 days antibiotic therapy and 15 cases for 14 days antibiotic therapy. C-reactive protein (CRP) and blood culture were repeated at 48 hours after stopping antibiotic therapy in all the babies in both groups. All babies were followed up on a weekly basis for a period of 4 weeks.
Results: No statistically significant difference was noted in both the groups regarding the clinical recovery, but the mean duration of hospital stay was statistically significant (p value=0.0001). After 4 weeks follow-up, there was no statistically significant relapse rate with 2 relapses in neonates who received 10 days antibiotics and 1 relapse in the 14-day antibiotic group (p value=0.54).
Conclusion: Ten days antibiotic therapy is effective as 14 days antibiotic therapy in culture proven neonatal sepsis.
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0