Ten Days Versus Fourteen Days Antibiotic Therapy in Culture Proven Neonatal Sepsis: Single Center Egyptian Experience
Elsayed Ibrahim Salama, Hassan Said Badr, Mostafa Hamed Mohammed.
Department of Pediatrics, National Liver Institute and Faculty of Medicine, Menoufyia University, Egypt.
Aim: To compare the efficacy of a 10 days course versus the conventional 14 days course of antibiotic therapy in neonatal sepsis proven by blood culture.
Methods: The study was done in the neonatal intensive care unit (NICU) in 30 neonates with culture positive neonatal sepsis. They were subdivided into 2 groups: 15 cases for 10 days antibiotic therapy and 15 cases for 14 days antibiotic therapy. C-reactive protein (CRP) and blood culture were repeated at 48 hours after stopping antibiotic therapy in all the babies in both groups. All babies were followed up on a weekly basis for a period of 4 weeks.
Results: No statistically significant difference was noted in both the groups regarding the clinical recovery, but the mean duration of hospital stay was statistically significant (p value=0.0001). After 4 weeks follow-up, there was no statistically significant relapse rate with 2 relapses in neonates who received 10 days antibiotics and 1 relapse in the 14-day antibiotic group (p value=0.54).
Conclusion: Ten days antibiotic therapy is effective as 14 days antibiotic therapy in culture proven neonatal sepsis.

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