ISSN - 0973-0958

Pediatric Oncall Journal View Article

Correlation between Proteinuria Degree and Neutrophil-To-Lymphocyte Ratio for the Early Diagnosis of Systemic Lupus Erythematosus in Children
Muhammad Adityansah1, Reni Ghrahani2, Gartika Sapartini2, Budi Setiabudiawan2.
1Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia,
2Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
Abstract
Background: Lupus nephritis (LN) increases mortality and morbidity in systemic lupus erythematosus (SLE) patients. Clinical and laboratory presentations for LN differ, and patients most commonly present in a state of acute kidney failure. One of the indicators of kidney involvement in SLE patients is proteinuria. Neutrophils and lymphocytes play an important role in the pathogenesis of LN. Neutrophil-to-lymphocyte ratio (NLR) is one of the known biomarkers for measuring the degree of LN disease activity, as measured by a simple blood test, and easily obtained in a cost-effective manner.
Objective: The aim of this study was to investigate the correlation between the degree of proteinuria and NLR in paediatric SLE patients.
Method: This study was conducted retrospectively, using a cross-sectional research method. Data were extracted from the medical records of 62 patients with paediatric SLE at the time of diagnosis. Patients were divided into two groups according to infection status. All patients had urine dipstick measurements for proteinuria. NLR was calculated by comparing the absolute neutrophil count with absolute lymphocyte number obtained from a patient's peripheral blood sample.
Result: There was an increase in NLR according to the positivity rate of proteinuria, but this was not statistically significant (P >0.05). There was no correlation between NLR and the degree of proteinuria in patients who were diagnosed with early SLE (P >0.05).
Conclusion: There was no significant correlation between NLR and the degree of proteinuria in paediatric patients with an early diagnosis of SLE.

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