ISSN - 0973-0958
Bilateral Exudative Retinal Detachment in a Case of Aplastic Anemia 07/22/2016 00:00:00 https://www.pediatriconcall.com/Journal/images/journal_cover.jpg
   
 
Bilateral Exudative Retinal Detachment in a Case of Aplastic Anemia
Tanvi Meha*, Anshul Raja**, Saksham Singh*, Anil Kumar Jaiswal*
*Department of Pediatrics, Patna Medical College and Hospital, Patna, Bihar and **Department of Radiodiagnosis, Eras Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Cite this article  Copy Citation
Meha T, Raja A, Singh S, Jaiswal KA. Bilateral Exudative Retinal Detachment in a Case of Aplastic Anemia. Pediatr Oncall J. 2016;13. doi: 10.7199/ped.oncall.2016.52

Address for Correspondence
Dr. Tanvi Meha, 403, Jaya Neelam Vihar, IAS Colony, Patna- 801503, Bihar.
 
Email
tanvimeha@yahoo.com
 
Keywords
aplastic anaemia, retinal detachment
 
A 7 years old female child presented to pediatric emergency with fever for 20 days and continuous bleeding from gums following tooth extraction for 8 days. On examination she looked ill, had pallor and was disoriented. She had petechial spots all over the body. Oral hygiene was poor and there was bleeding from gums. Her vision was significantly impaired and she could count fingers only from a distance of 0.5 meters. Complete blood count revealed pancytopenia. Bone marrow aspirate showed hypocellular marrow. Serological analysis for Parvovirus B19 infection was negative. Funduscopy of both eyes showed bilateral exudative retinal detachment which was further confirmed by Ultrasound B-Scan.
Aplastic anaemia is characterized by peripheral pancytopenia coupled with hypoplastic or aplastic bone marrow. It is typically characterized by anemia, leucopenia and thrombocytopenia which clinically manifests as fatigue, cardiac failure, infection and bleeding. (1) Besides gingival or nasal bleeding, patients with aplastic anaemia may present with ocular hemorrhages. (2) Common retinal findings in aplastic anemia include intra-retinal hemorrhages, Roth’s spot hemorrhages, cotton-wool spots, retinal exudates, venous dilation, optic nerve pallor and retinal detachment. (3,4) Some blood dyscrasias including aplastic anemia have an association with exudative retinal detachment. The exact pathophysiology of anemic retinopathy is not clearly understood, but it seems to be related to retinal hypoxia. These changes generally occur in patients with severe anemia or when thrombocytopenia (abnormally low platelet count) is present. According to various studies, aplastic anaemia patients with ocular findings appeared to have various degrees of disseminated intravascular coagulopathy syndrome with serious rheological shifts and hemorrhagic diathesis. This is particularly noted in Parvovirus B19 induced aplastic crisis. (5) The associated exudative retinal detachment may undergo spontaneous resolution if the causative disease is controlled. Thus the treatment is aimed at correcting hematological parameters. Coordination of medical and surgical care with the hematology service is strongly advisable to stabilize hematologic parameters prior to undertaking a vitreo-retinal procedure.
 
Funding
None
Conflict of Interest
None
References :
  1. Ghosh S, Biswas PN, Mukhopadhyay S, Bhaduri G. Posthepatitis aplastic anaemia presenting only with bilateral vision loss. J Indian Med Assoc. 2007;105:524.  [PubMed]
  2. Lang GE, Spraul CW, Lang GK. Ocular changes in primary hematologic diseases. Klin Monatsbl Augenheilkd 1998;212:419-27.  [CrossRef]  [PubMed]
  3. Aisen ML, Bacon BR, Goodman AM, Chester EM. Retinal abnormalities associated with anemia. Arch Ophthalmol. 1983;101:1049–1052.  [CrossRef]  [PubMed]
  4. Mansour AM, Salti HI, Han DP, Khoury A, Friedman SM, Salem Z et al. Ocular findings in aplastic anemia. Ophthalmologica.2000;214:399–402.  [CrossRef]  [PubMed]
  5. Suzuki J, Goto H, Usui M, Sakai J. Serous retinal detachment in a patient with aplastic anemia associated with parvovirus B19 infection. Graefes Arch Clin Exp Ophthalmol. 2007; 245: 324-326.  [CrossRef]  [PubMed]
Last Updated : 01 October 2016 Vol 13 Issue 4 Art #52
DOI No : https://doi.org/10.7199/ped.oncall.2016.52
Cite this article as: :
Meha T, Raja A, Singh S, Jaiswal KA. Bilateral Exudative Retinal Detachment in a Case of Aplastic Anemia. Pediatr Oncall J. 2016;13. doi: 10.7199/ped.oncall.2016.52
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0