Rash
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Rash
16/11/2010
16/11/2010
Ira Shah
https://www.pediatriconcall.com/Journal/images/journal_cover.jpg
Dr Ira Shah.
Medical Sciences Department, Pediatric Oncall, Mumbai, India.
ADDRESS FOR CORRESPONDANCE
Dr Ira Shah, 1, B Saguna, 271, B St Francis Road, Vile Parle {W}, Mumbai 400056. India |
Clinical Problem
An 11 year old HIV infected girl on 3 drugs ART consisting of Zidovudine {AZT}, Lamivudine {3TC} and Efavirenz {EFV} since past 1 year presented with generalized swelling all over body with itching and rash since 5 days. She was given Nevirapine {NVP} instead of EFV by a local hospital 7 days ago. She also has NVP induced rash 1 year ago when she was first started on ART and hence shifted to EFV.
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What could be the cause of present problems_?
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Discussion
Since the child had skin rashes earlier with Nevirapine and now again has received NVP, one may very well assume that the present swelling and itching and rash could also be due to NVP. The swelling is suggestive of angioedema and rash and itching is suggestive of urticaria. In this child, blood counts demonstrated eosinophilia {absolute eosinophil count = 2,942 cells, cumm} and rash subsided with steroids and antihistaminics.
Thus, one must never restart NVP in a child who has already had allergic reactions to the same as these allergic reactions may be life threatening. Also, ideally if there is an allergic reaction to any one drug of the NNRTI group, one must avoid all drugs in that group. However, since the child could not afford protease inhibitors, we have put the child on Efavirenz and she is not having any problems with the same.
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| Compliance with ethical standards |
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Funding: None
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Conflict of Interest: None
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Cite this article as:
Shah I. Rash. Pediatr Oncall J. 2011;8: 29.
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