They are used as sedatives, hypnotics, intravenous anaesthetics and in treatment of various diseases. They are classified as: 1. Long acting: action lasts for 8 to 16 hours. eg. sodium barbitone, phenobarbitone and mephobarbitone 2. Intermediate acting: action lasts for 8 to 10 hours. eg. butobarbitone, amylobarbitone 3. Short acting: action lasts for 3 to 6 hours. eg. cylcobarbitone, hexabarbitone, secobarbital, pentobarbital 4. Ultra short acting: thiopentone and hexobarbitone
Route :
Fatal Dose :
Fatal Period :
1 to 2 days
Clinical Picture :
The stages of barbiturate poisoning are as follows: 1. awake, competent 2. sedated, reflexes present 3. comatose and reflexes present 4. comatose and areflexia 5. comatose with respiratory and circulatory disturbances • Barbiturate automatism: with therapeutic dose there is induction of sleep and sometimes there results mental confusion so that person takes more drug • In acute poisonin: giddiness, ataxia, slurred speech, stupor, flaccid limbs, areflexia, diplopia, absent bowel sounds and pupils that show alternate contraction and dilation. face becomes cyanosed, hypotension, hypothermia, bullae or blisters on skin{ barbiturate bullae}
Treatment :
• Gastric lavage • enema and purgatives • Maintain respiration • Bemigrid, 50mg and Daptazol 15mg in i.v. drip • Coramine, 5 to 10 ml i.v. • Maintenance of BP • Prophylactic antibiotics • Diuresis, peritoneal or hemodialysis • Symptomatic treatment
04/11/2020 18:12:38 Barbiturates
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