Nitrates and nitrites
1. Inorganic nitrates: sodium nitrate{ tastes like sodium chloride, used by weavers as a mordant}, potassium nitrate, silver nitrate 2. Organic nitrates: nitroglycerin, iso sorbide dinitrate 3. Inorganic nitrites: amyl nitrite, isobutyl nitrite, sodium nitrite 4. Organic nitrites: bismuth sub nitrate in contaminated well water may be converted by intestinal bacteria into nitrites and causes poisoning
Route :
Fatal Dose :
sodium nitrate - 1 to 2 gms, nitroglycerin – 200mg, silver nitrate – 2 to 10 gms
Fatal Period :
few hours to few days
Mechanism of action :
Sodium nitrate causes relaxation of smooth muscles, especially of blood vessels and in toxic doses comnerts hemoglobin to methemoglobin
Clinical Picture :
• Throbbing headache, vertigo, low BP, palpaitations, • cold and cyanotic, nausea , vomiting, diarrhea, syncope • cyanosis, anoxia • Hyperapnoea, later dyspnoea, slow pulse, increased intracranial tension • paralysis, convulsions, coma
Treatment :
• Emesis • Gastric lavage • If methhemoglobinemia More than 30 percent, inject methylene blue {1 percent soln} or 1 to 2 mg, kg orally • Exchange transfusion, especially in infants • Symptomatic
04/11/2020 18:27:30 Nitrates and Nitrites
ask a doctor
Ask a Doctor
Disclaimer: The information given by is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0