Thalassemia Management

M R Lokeshwar
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Thalassemia Management - Clinical Manifestations
The spectrum of clinical manifestations of Beta-Thalassemia varies widely. One end of the spectrum is the serious homozygous form (Thalassemia Major) that presents in early infancy (6-18 months) with progressive pallor, splenohepatomegaly and bony changes and if left untreated, is invariably fatal during the first few years of life; and the other end of the spectrum is a heterozyous form (thalassemia minor) in which the patient can lead a practically normal life except for a mild persistent anemia and have a normal life span. In between these two extremes are forms with varying degrees of clinical manifestations of anemia, splenohepatomegaly and bony changes who maintain their life fairly comfortably and are not dependent on blood transfusion for their survival and are called thalassemia intermedia and are also homozygous.


References
Thalassemia Management Thalassemia Management 12/27/2013
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