Pediatric Oncall
Diagnostic Dilemma
Home | All Discussions | Submit Dilemma  

Antituberculous drugs and rash


Author: Pediatric Oncall
Question
A 4½ years old girl presented with fever for 15 days, headache for 7 days and stiffness of legs for 7 days. She had meningeal signs on examination. CSF showed 3,900 cells/cumm (78% polymorphs, 22% lymphocytes), proteins 90 mg/dl, glucose 43 mg%. HIV ELISA was negative. Hemoglobin was 11.8 gm/dl, WBC count was 16,000/cumm (89% polymorphs, 11% lymphocytes) and ESR was 102 mm at end of 1 hour. There is history of tuberculosis in a girl in the neighbourhood. CT brain and cervical spine showed 2.3 x 0.5 cm intraspinal abscess compressing cord at C1 & C3 levels. MRI spine showed an anterior epidural abscess measuring 6.5 x 1.0 cm diameter from C1 – C4 with marked enhancement of adjacent leptomeninges with bilateral basal pleural effusion with basal collapse consolidation and a large multiloculated left psoas abscess extending from L1 till mid pelvis with normal spinal cord. She was treated with 4 drug antituberculous therapy (ATT) consisting of isoniazid, rifampicin, ethambutol and pyrazinamide. However she developed morbilliform rash and fever with elevated liver enzymes (SGPT = 139 IU/L, SGOT = 225 IU/L) due to ATT. She was then shifted to alternate ATT consisting of Ofloxacin, Ethambutol & Streptomycin. Her liver enzymes decrease & fever and rash subsided.

Previous Discussions View All

P
PUO with hematuria
Pediatric Oncall
A 10 years old girl presented with fever for a month and microscopic hematuria. She had persistent headache. There was no organomegaly and systemic examination was normal. On investigations, hemogram,....
F
Forgotten dog bite
Pediatric Oncall
A 10 years old boy had a dog bite by a street dog a year ago. The boy did not inform his parents that he had a dog bite. A year later, he informed his parents about the dog bite. The street dog was not seen after a few days after the bite.
A
Acute hepatitis with Positive Hepatitis A virus IgM and Positive HBsAg
Pediatric Oncall
A 9 1/ 2 years old boy was diagnosed to have acute hepatitis. The referring pediatrician had done Hepatitis A virus {HAV} IgM which was positive. HBsAg which was also positive. Mother was also HBsAg p....
S
Skin TB with Vascular occlusion
Pediatric Oncall
A 3 years old girl presented with hyper pigmented macules over left inguinal region. She was diagnosed to have cutaneous TB on skin biopsy and was on anti TB therapy for past 1 year. A repeat skin bio....
G
Granuloma – Is it TB_?
Pediatric Oncall
A 15 years old boy was diagnosed to have neurocysticercosis in June 2011. CT scan showed left parietal nodular lesion with mild perilesional edema with tiny scolex. A repeat MRI scan in July 2011 show....

EAP 2017
Ask a Doctor
Join Us
Pediatric Oncall
Medical Calculators
Drug Center
Pediatric Oncall Journal
Parenting
Vaccine Reminder
Home
About Us
Link To Us
Terms & Conditions
Privacy Policy
Online Ordering Policy
Sitemap
Feedback
Partner Sites
HIV in Childern
Creative Catchy Ideas
Medical ADRIS
Vaccine Reminder
Pediatric Oncall Journal
Advertisements By
Mega CV by Aristo
IndoIV by Sun Pharma
Upcount By DelCure

Infection in Children

Pediatric Liver Disorders

Pediatric HIV

Tuberculosis
Copyright © 2001 - 2017 Pediatric Oncall All Rights Reserved. All trademarks used are the properties of their respective owners.
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.