Drug Index

Captopril

 
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Mechanism :

Captopril is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II.


Indication :

• Hypertension

• Congestive cardiac failure


Contraindications :

Captopril is contraindicated in patients who are hypersensitive to this product or any other angiotensin-converting enzyme inhibitor. Avoid in neonates, in volume depletion and renovascular disease.


Dosing :

Premature neonates: 0.01 mg/kg orally 8-12 hourly;

Neonates: Initially 0.05-0.1 mg/kg/dose orally 1-3 times and increase upto 0.5 mg/kg/dose 1-4 times daily;

Infants: 0.15-0.3 mg/kg orally, Increase upto 6 mg/kg/day in 1-4 divided doses;

Child: Initially 0.3-0.5 kg/dose orally and increase upto 6 mg/kg/day in 2-4 divided doses;

Older children: 6.25-12.5 mg/dose orally, 1-2 times a day and increased upto a maximum of 6 mg/kg/day in 2-4 divided doses.

Adolescents: 12.5-25 mg/dose 1-2 times a day and increased by 25 mg/dose every 1-2 weeks upto a maximum of 450 mg/day.


Adverse Effect :

Neutropenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, rash, pruritus, fever, arthralgia, eosinophilia, hypotension, angioedema, cough.


Interaction :

Diuretics: A precipitous reduction of blood pressure usually within the first hour of receiving the initial dose of captopril.
Potassium-sparing diuretics such as Spironolactone, Triamterene, or Amiloride: Since captopril decreases aldosterone production, elevation of serum potassium may occur.
Nonsteroidal Anti-Inflammatory Agents: Reduces the antihypertensive effect of captopril
Lithium: Increased serum lithium levels and symptoms of lithium toxicity.


07/18/2019 01:56:45 Captopril
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