Drug Index

Lisinopril

 
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Mechanism :

Lisinopril is an ACE inhibitor which is used in the treatment of hypertension, congestive heart failure and following myocardial infarction in hemodynamically stable patients.


Indication :

• Hypertension

• Congestive Heart Failure


Contraindications :

In patients who are hypersensitive to this product and in patients with a history of angioneurotic edema relating to previous treatment with an angiotensin converting enzyme inhibitor.


Dosing :

Hypertension: Above 6 years; GFR <30 ml/minute/1.73 m².

0.07 mg/kg orally once every day initially and doses are increased gradually according to blood pressure levels. Max: 0.61 mg/kg/day or 40 mg/day.


Adverse Effect :

Neutropenia, agranulocytosis, thrombocytopenia, anemia, pancytopenia, rash, pruritus, arthralgia, fever, eosinophilia. Hypotension, angioedema, cough, dizziness, headache, kidney disease.


Interaction :

Diuretics: A precipitous reduction of blood pressure usually within the first hour of receiving the initial dose.
Potassium-Sparing Diuretics such as Spironolactone, Triamterene, or Amiloride: Since it decreases aldosterone production, elevation of serum potassium may occur.
Nonsteroidal Anti-Inflammatory Agents: Reduces the antihypertensive effect.
Lithium: Increased serum lithium levels and symptoms of lithium toxicity.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Initial dose 2.5 mg daily and titrate according to response
10-20Initial dose 2.5 mg daily and titrate according to response
<10Initial dose 2.5 mg daily and titrate according to response

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

No dose adjustments are recommended.
07/30/2020 07:28:34 Lisinopril
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