Drug Index

Enalapril

 
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Mechanism :

Enalapril is a specific competitive inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I to angiotensin II.


Indication :

• Hypertension

• Hypertensive crisis

• Congestive cardiac failure

• Proteinuria


Contraindications :

Enalapril is contraindicated in patients who are hypersensitive to this product or any other angiotensin-converting enzyme inhibitor. Avoid in neonates, in volume depletion and renovascular disease. Not recommended in neonates and in pediatric patients with glomerular filtration rate <30 mL/min/1.73 m2.


Dosing :

Hypertension:

Use in children above 1 month of age.

Oral: 0.1-0.5 mg/kg/day PO OD or in 2 divided doses. Max: 40 mg/day. Adjust according to blood pressure.

IV: 0.01-0.02 mg/kg/day in two divided doses.

Hypertensive crisis:

0.05-0.1 mg/kg given as an intravenous injection.


Adverse Effect :

Neutropenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, rash, pruritus, arthralgia, fever, eosinophilia, hypotension, angioedema, cough.


Interaction :

Diuretics: A precipitous reduction of blood pressure usually within the first hour of receiving the initial dose of enalapril.
Potassium-sparing diuretics such as spironolactone, triamterene, or amiloride: Since enalapril decreases aldosterone production, elevation of serum potassium may occur.
Nonsteroidal anti-inflammatory agents: Reduces the antihypertensive effect of enalapril.
Lithium: Increased serum lithium levels and symptoms of lithium toxicity.


07/14/2019 06:42:11 Enalapril
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