Drug Index

Aglucerase

Synonym :

Glucocerebrosidase Enzyme

Mechanism :

Alglucerase catalyzes the hydrolysis of the glycolipid glucocerebroside to glucose and ceramide as part of the normal degradation pathway for membrane lipids. Glucocerebroside is primarily derived from hematologic cell turnover. Gaucher disease is characterized by a functional deficiency in b-glucocerebrosidase enzymatic activity and the resultant accumulation of lipid glucocerebroside in tissue macrophages which become engorged and are termed Gaucher cells.


Indication :

  • Type I Gaucher’s disease

Contraindications :

There are no known contraindications.


Dosing :

IV infusion over 1-2 hours: 2.5 units/kg of body weight 3 times a week. Can increase to 60 units/kg once in 1-4 weeks. 60 units/kg every 2 weeks is the recommended regime.

Adverse Effect :

There are no known contraindications.

Pruritis, burning and swelling or sterile abscess at the site of venepuncture. Fever, chills, abdominal discomfort, nausea, vomiting, hypersensitivity like urticaria/angioedema, chest discomfort, hypotension.


Hepatic Dose :

No dosage adjustments are recommended.
08/11/2024 01:26:07 Aglucerase
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0