Drug Index

Amiloride

 
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Mechanism :

Amiloride is a potassium-conserving drug that possesses weak natriuretic, diuretic and antihypertensive activity. Co-administration with a thiazide or loop diuretic, decreases the urinary excretion of magnesium which occurs when a thiazide or loop diuretic is used alone. Amiloride has potassium-conserving activity in patients receiving kaliuretic-diuretic agents.


Indication :

• Hypokalemia when thiazides or other kaliuretic diuretics are used

• Nephrogenic diabetes insipidus

• Hypertension (off-label)


Contraindications :

Hyperkalemia

Antikaliuretic Therapy or Potassium Supplementation

Nephrogenic diabetes insipidus in infants


Dosing :

Safety and efficacy for use in pediatric patients has not yet been established.0.625 mg/kg PO given once daily; gradually dose can be increased. Maximum dosage: 20 mg/day.

Nephrogenic diabetes insipidus (along with hydrochlorothiazide):

0.3 mg/kg/day in divided doses 3 times daily.


Adverse Effect :

Hyperkalemia, nausea, anorexia, abdominal pain, flatulence, diarrhea, constipation, appetite changes, muscle cramps, dizziness, encephalopathy, cough, dyspnea.


Interaction :

Angiotensin-converting enzyme inhibitor: Risk of hyperkalemia may be increased.
Lithium: Reduce its renal clearance and add a high risk of lithium toxicity.
NSAIDS: Reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.


07/17/2019 10:39:10 Amiloride
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