Drug Index

Caffeine

 
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Mechanism :

Caffeine is structurally related to other methylxanthines, theophylline and theobromine. It is a bronchial smooth muscle relaxant, a CNS stimulant, a cardiac muscle stimulant and a diuretic.


Indication :

• Apnea in neonates


Contraindications :

Caffeine and Sodium Benzoate solution in paediatrics.


Dosing :

Apnea of prematurity:

Loading dose: 10 to 20 mg/kg caffeine base (20 mg/kg caffeine citrate) orally or IV over 30 min.

Maintenance dose: 5-10 mg/kg caffeine base orally or IV OD.


Adverse Effect :

Tachycardia, extrasystole, palpitations, arrhythmias, insomnia, restlessness, excitement, nervousness, scintillating scotoma, tinnitus, muscular tremor, headache, light headedness, urticaria, dry skin, rash, vomiting, nausea, diarrhea, stomach pain, necrotizing enterocolitis, gastritis, diuresis, hyperglycemia.


Interaction :

Theophylline: Interconversion between caffeine and theophylline has been reported in preterm neonates.
Cimetidine, Disulfiram, Fluoroquinolones, Oral Contraceptives, Mexiletine and Ketoconazole: Decrease caffeine elimination.

Lithium: Decrease plasma levels of lithium.
Phenytoin: Decrease caffeine levels.


07/14/2019 19:28:11 Caffeine
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