Drug Index

Vecuronium

 
print

Mechanism :

It is a muscle-relaxing drug and acts by preventing the binding of acetylcholine to the muscle end plate, which is a chemical substance that helps in muscle contraction. Vecuronium is a nondepolarizing neuromuscular blocking agent. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium. It is the drug of choice in patients with renal impairment as it is excreted by the biliary system.


Indication :

• Anaesthesia

• Ventilation


Contraindications :

Contraindicated in patients known to have hypersensitivity to vecuronium bromide.


Dosing :

<5 month: Initially, 10-20 mcg/kg IV, increased if necessary according to response.

>5 month: Initially, 80-100 mcg/kg IV single dose.

Alternatively, 30-50 mcg/kg IV after clinical recovery from neuromuscular blockade of suxamethonium.

As an adjunct to general anaesthesia in children 1-10 years old:

0.1 mg/kg IV; repeat hourly as and when needed; OR

Continuous Infusion: 0.05-0.07 mg/kg/hour IV.


Adverse Effect :

Very few side effects reported. Vecuronium has only a weak capacity for inducing local histamine release. Respiratory insufficiency, alkalosis, hypotension.


Interaction :

Aminoglycosides, Metronidazole, Polymyxins, Suxamethonium, Nifedipine, Verapamil, Propranolol, Procainamide, Quinidine, Lithium and Parenteral Magnesium, high doses of Thiopental, Ketamine, Fentanyl, Beta-Blockers and Diuretics: Enhanced effect.
Corticosteroids, Phenytoin and Carbamazepine: Decreased effect.


08/06/2019 12:30:50 Vecuronium
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0