Drug Index

Suxamethonium

 
print
Synonym :

Succinyl Choline

Mechanism :

Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site.


Indication :

• Neuromuscular blockade for tracheal intubation


Contraindications :

Succinylcholine is contraindicated in persons with personal or familial history of malignant hyperthermia, skeletal muscle myopathies, known hypersensitivity to the drug, in patients after the acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury, because succinylcholine administered to such individuals may result in severe hyperkalemia which may result in cardiac arrest.


Dosing :

Infants and smaller children: 2 mg/kg IV single dose.

Adolescents: 1 mg/kg IV single dose or 3-4 mg/kg deep IM. Max: 150 mg.

Maintenance: 0.3-0.6 mg/kg IV every 5-10 mins as needed.


Adverse Effect :

Succinylcholine causes profound muscle relaxation resulting in respiratory depression to the point of apnea. Hypersensitivity reactions, including anaphylaxis, may occur in rare instances. The following additional adverse reactions have been reported: cardiac arrest, malignant hyperthermia, arrhythmias, bradycardia, tachycardia, hypertension, hypotension, hyperkalemia, prolonged respiratory depression or apnea, increased intraocular pressure, muscle fasciculation, jaw rigidity, postoperative muscle pain, rhabdomyolysis with possible myoglobinuric acute renal failure, salivary gland enlargement, excessive salivation,
and rash.


Interaction :

Promazine, Oxytocin, Aprotinin, Certain Non-Penicillin Antibiotics, Quinidine, B-Adrenergic Blockers, Procainamide, Lidocaine, Trimethaphan, Lithium Carbonate, Magnesium Salts, Quinine, Chloroquine, Diethyl Ether, Isoflurane, Desflurane, Metoclopramide, and Terbutaline: May enhance the neuromuscular blocking action of succinylcholine.
Chronically administered oral contraceptives, glucocorticoids, or certain Monoamine Oxidase Inhibitors: The neuromuscular blocking effect of succinylcholine may be enhanced by drugs that reduce plasma cholinesterase activity.


08/06/2019 12:17:15 Suxamethonium
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0