Drug Index

Pancuronium

 
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Mechanism :

Pancuronium is a nondepolarizing neuromuscular blocking agent. It acts by competing for cholinergic receptors at the motor end-plate. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine and edrophonium.


Indication :

• Neuromuscular blockade

• Ventilation


Contraindications :

Contraindicated in patients known to have hypersensitivity to pancuronium bromide. Use with caution in severe renal impairment as duration of action is prolonged. Since pancuronium causes relaxation of the respiratory muscles, respiration must be assisted in all patients.


Dosing :

Neonates: IV loading 0.02 mg/kg followed by maintenance IV 0.05-0.1 mg/kg/dose every 30 mins to 4 hours, as and when needed.

1 month-18 years: 0.04-0.1 mg/kg IV initially followed by 0.015-0.01 mg/kg every half to one hour, OR continuous IV: 0.1 mg/kg/hr.


Adverse Effect :

Tachycardia, hypertension, excessive salivation, transient rashes, wheezing, histamine release.


Interaction :

Aminoglycosides, Metronidazole, Polymyxins, Suxamethonium, Nifedipine, Verapamil, Propranolol, Procainamide, Quinidine, Lithium and Parenteral Magnesium, High Doses of Thiopental, Ketamine, Fentanyl, Beta-Blockers and Diuretics: Enhanced effect.
Corticosteroids, Phenytoin and Carbamazepine: Decreased effect.


08/10/2019 20:33:42 Pancuronium
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