Drug Index

Amlodipine

 
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Mechanism :

Amlodipine is a dihydropyridine calcium antagonist (slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.


Indication :

• Hypertension


Contraindications :

Amlodipine is contraindicated in dihydropyridine hypersensitivity. It can cause liver damage.


Dosing :

For <6 years of age: Safety and efficacy not established.

For >6 years of age: 2.5-5 mg/day oral.


Adverse Effect :

Headache, edema, flushing, dizziness, palpitation, nausea, male sexual dysfunction, abdominal pain, somnolence, vomiting.


Interaction :

Itraconazole and Fluconazole: Inhibits amlodipine metabolism.
Rifampicin: Decreases effects of amlodipine.
Cyclosporine: Levels of cyclosporine are increased.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Use with caution as elimination half-life of amlodipine is prolonged in patients with hepatic disease. Start with a reduced dose and adjust dosage based on clinical response.
04/06/2020 21:27:06 Amlodipine
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