Drug Index

Amlodipine

 
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Mechanism :

Amlodipine is a dihydropyridine calcium antagonist (slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.


Indication :

• Hypertension


Contraindications :

Amlodipine is contraindicated in dihydropyridine hypersensitivity. It can cause liver damage.


Dosing :

For <6 years of age: Safety and efficacy not established.

For >6 years of age: 2.5-5 mg/day oral.


Adverse Effect :

Headache, edema, flushing, dizziness, palpitation, nausea, male sexual dysfunction, abdominal pain, somnolence, vomiting.


Interaction :

Itraconazole and Fluconazole: Inhibits amlodipine metabolism.
Rifampicin: Decreases effects of amlodipine.
Cyclosporine: Levels of cyclosporine are increased.


07/14/2019 20:29:08 Amlodipine
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