Amodiaquine
Mechanism :
Amodiaquine is a histamine N-methyltransferase inhibitor.
Indication :
Contraindications :
Severe liver impairment and hypersensitivity.
Dosing :
10 mg base/kg OD x 3 days combined with
primaquine for chloroquine-resistant vivax malaria.
Adverse Effect :
Severe liver impairment and hypersensitivity.
Nausea, vomiting, itching, gastritis, headache, loss of vision, skin rash, muscle pain, loss of hearing and greying of hair.
Hepatic Dose :
Elevation of serum aminotransferases has been reported. Idiosyncratic acute liver injury can occur on treatment. It is avoided in patients with hepatic impairment.