Drug Index


Synonyms :

Aminohydroxypropylidene Diphosphonate, Disodium Pamidronate

Mechanism :

Lowers serum calcium concentration by binding to the bone and inhibiting osteoclast mediated calcium resorption, it has no effect on renal tubular calcium handling.

Indication :

• Hypercalcemia

• Osteogenesis imperfecta

• Steroid induced Osteoporosis

• Idiopathic Juvenile Osteoporosis

• Paget’s disease

Contraindications :


Severe renal impairment

Hypersensitivity to pamidronate

Dosing :


0.5 to 1 mg/kg slow IV infusion over 24 hours one time. A second dose, identical to the first one is given if significant hypercalcemia persists or recurs. A minimum of 7 days should elapse between doses.

Osteogenesis Imperfecta:

14 days-23 months: 0.5 mg/kg IV once a day x 3 days every 2 months.

For first cycle on Day 1: 0.25 mg/kg IV.

2-3 years: 0.75 mg/kg IV once a day x 3 days every 3 months.

For first cycle on Day 1: 0.38 mg/kg IV.

4 years and older: 1 mg/kg IV once a day for 3 days every 4 months.

For first cycle on Day 1: 0.5 mg/kg IV.

Maximum dose: 90 mg/dose, 9 mg/kg total annual dose. Give for 1-4 years.

Osteopenia and Osteoporosis:

3 years and older: 0.4-1 mg/kg IV once a day x 3 days every 3-6 months for 1-4 years. Maximum dose: 90 mg/dose.

Adverse Effect :

Common: Hypocalcemia, hypomagnesemia, hypophosphatemia, hypokalemia. anemia, hypertension, fever, abdominal cramps, bone pain, nausea/vomiting, injection site reactions and cough.

Rare: Osteonecrosis of the jaw, reactivation of herpes zoster and simplex, rash and allergies, renal disorders, hematuria, dizziness, paresthesia, neutropenia, thrombocytopenia, visual disturbance, seizures, uveitis, scleritis.

Interaction :

Cidofovir, streptozocin.

03/14/2020 02:41:02 Pamidronate
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0