Drug Index

Physostigmine

 
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Mechanism :

It is an anticholinesterase agent used as a muscle-relaxant. It is used in the diagnosis and treatment of myasthenia gravis. It is used in combination with other drugs to relieve intra-ocular pressure encountered in glaucoma. It is the antidote used for atropine poisoning.


Indication :

• For the treatment of glaucoma

• Treatment of severe anticholinergic toxicity.


Contraindications :

Hypersensitive to sulfites, GI obstruction, GU tract obstruction, Asthma, Gangrene, Diabetes mellitus, Severe cardiovascular disease, Arrhythmias, Glaucoma, angle-closure, Neonates.


Dosing :

Anticholinergic drug overdosage:

Initially 0.02 mg/kg/dose IV over 1 min. Maybe repeated at 5-10 min interval if required. Maximum dose: 0.5 mg/min and cumulative dose: 2 mg.


Adverse Effect :

Cholinergic crisis, seizures, tremor, fasciculation, bronchoconstriction, bradycardia, diaphoresis, hallucinations, hypotension and vomiting.


Interaction :

Avoid/Use Alternative:
Bethanechol, Cevimeline, Pilocarpine, Succinylcholine.


07/19/2019 03:52:54 Physostigmine
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