Drug Index

Sevelamer

 
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Mechanism :

Sevelamer binds phosphate within the intestinal lumen, limiting absorption and decreasing serum phosphate concentrations.


Indication :

• Control of serum phosphorous


Contraindications :

Hypersensitivity to sevelamer or any component of the formulation; bowel obstruction: hypophosphatemia, active mucosal injury.


Dosing :

Safety and efficacy not established in children <6 years.

Body surface area (BSA) ≥0.75 to <1.2 sqm: 800 mg per meal; titrate as needed by 400 mg per dose at 2 week intervals.

BSA ≥1.2 sqm: 1,600 mg per meal; titrate as needed by 800 mg per dose at 2 week intervals.


Adverse Effect :

Metabolic acidosis, vomiting, nausea, diarrhea, dyspepsia, abdominal pain, constipation, flatulence, peritonitis.


Interaction :

Cyclosporine, Tacrolimus: Sevelamer may decrease the serum concentration of Cyclosporine.
Levothyroxine: Sevelamer may decrease the serum concentration of Levothyroxine.
Mycophenolate: Sevelamer may decrease the serum concentration of Mycophenolate.
Quinolones: Sevelamer may decrease the absorption of Quinolones.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDUnlikely to be dialysed. Dose as in normal renal function
HDF/High fluxUnlikely to be dialysed. Dose as in normal renal function
CAV/VVHDUnlikely to be dialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
04/07/2020 01:31:02 Sevelamer
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