Drug Index

Terbinafine

 
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Mechanism :

Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations terbinafine is fungicidal against dermatophytes, moulds and certain dimorphic fungi. The activity against yeasts is fungicidal or fungistatic, depending on the species. Terbinafine interferes specifically with fungal sterol biosynthesis by inhibition of squalene epoxidase in the fungal cell membrane. This leads to a deficiency in ergosterol and to an intracellular accumulation of squalene, resulting in fungal cell death.


Indication :

• Fungal infection


Contraindications :

Contraindicated in patients with a hypersensitivity to terbinafine or any of the excipients. Avoid contact with eyes.


Dosing :

Oral: Tinea capitis: Use in children >4 years of age.

<25 kg: 125 mg/day for 6 weeks.

25-35 kg: 187.5 mg/day for 6 weeks.

>35 kg: 250 mg/day for 6 weeks.

Topical: Use in children >12 years. Available as 1%w/w cream, lotion, gel.

Apply twice daily for 1-4 weeks.


Adverse Effect :

Headache, loss of appetite, dyspepsia, nausea, mild abdominal pain, diarrhea, urticaria. Rarely, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis. If progressive skin rash occurs, treatment with terbinafine should be discontinued.


Interaction :

Rifampicin: Plasma concentration is reduced.
Cimetidine: Plasma concentration is increased.


08/06/2019 12:17:22 Terbinafine
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