Drug Index

Amikacin

 
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Mechanism :

Semi-synthetic aminoglycoside. Inhibits protein synthesis in susceptible bacteria by binding to ribosomal subunits.


Indication :

• Amikacin is usually effective against Pseudomonas, Klebsiella, Enterobacter, Serratia, Proteus, and E. coli; documented infection of mycobacterial organisms susceptible to amikacin.


Contraindications :

A history of hypersensitivity to amikacin is a contraindication for its use.


Dosing :

Adjust dose according to serum levels.

Neonates ≤7 days:

≤29 weeks of gestational age: 18 mg/kg IV/IM every 48 hours.

30-33 weeks gestational age: 18 mg/kg IV/IM every 36 hours.

≥34 weeks gestational age: 15 mg/kg IV/IM every 24 hours.

Neonates >7 days:

>30-33 weeks of gestational age: 15 mg/kg IV/IM every 24 hours.

Neonates 8-28 days and <29 weeks gestational age: 15 mg/kg IV/IM every 36 hours.

Neonates aged >28 days old and >29 weeks gestational age: 15 mg/kg IV/IM every 24 hours.

Infants and children: 15 mg/kg IV/IM every 24 hours.


Adverse Effect :

Ototoxicity, nephrotoxicity, neuromuscular blockade, fever, headache, dizziness, drowsiness, ataxia, vertigo, rash, nausea, vomiting, eosinophilia, anemia, leukopenia.


Interaction :

Vancomycin, Cephalosporin, Cyclosporine, Furosemide, Cisplatin, Amphotericin: Increases chances of ototoxicity and nephrotoxicity
Non-depolarising muscle relaxants: Enhances effect.
Neostigmine, Pyridostigmine: Antagonises effect.


08/10/2019 20:35:24 Amikacin
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