Drug Index


Mechanism :

Aminoglycoside antibiotic. Enzymes that degrade gentamicin and tobramycin do not degrade netilmicin. It is active against both gram positive and gram-negative bacterial infections.

Indication :

  • Serious gram-negative infections resistant to Gentamicin

Contraindications :

Hypersensitivity to netilmicin and myasthenia gravis is a contraindication to its use. Patients should be well hydrated during therapy, and renal function should be monitored. Dose adjustment is required in impaired renal function.

Dosing :

Premature or full-term neonates, 1 week of age or less:
6 mg/kg IV daily in two divided doses.
Neonates over 1 week of age and infants:
7.5-9.0 mg/kg daily IV in three divided doses.
6.0-7.5 mg/kg daily IV in three divided doses.
The duration of treatment is usually 7-14 days.

Adverse Effect :

Ototoxicity and nephrotoxicity. All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and also cause neuromuscular blockade.

Interaction :

Vancomycin, Cephalosporin, Cyclosporine, Furosemide, Cisplatin, Amphotericin: Increases chances of ototoxicity and nephrotoxicity.
Non-Depolarising Muscle Relaxants: Enhances effect.
Neostigmine, Pyridostigmine: Antagonises effect.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-504–7.5 mg/kg once daily. Monitor levels
10-203–4 mg/kg once daily. Monitor levels
<102 mg/kg once daily. Monitor levels

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. IV: 2 mg/kg on alternate days IP: 7.5–10 mg/L per exchange. Monitor levels
HDDialysed. Administer 2 mg/kg at the end of each dialysis session. Monitor levels
HDF/High fluxDialysed. Administer 2 mg/kg at the end of each dialysis session. Monitor levels
CAV/VVHDDialysed. Dose as in GFR=10– 20 mL/min. Monitor levels

Hepatic Dose :

No dosage adjustments are recommended.
12/24/2023 07:26:14 Netilmicin
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