Drug Index

Netilmicin

 
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Mechanism :

Aminoglycoside antibiotic. Enzymes that degrade gentamicin and tobramycin do not degrade netilmicin. It is active against both gram positive and gram-negative bacterial infections.


Indication :

• Serious gram-negative infections resistant to Gentamicin


Contraindications :

Hypersensitivity to netilmicin and myasthenia gravis is a contraindication to its use. Patients should be well hydrated during therapy, and renal function should be monitored. Dose adjustment is required in impaired renal function.


Dosing :

IV/IM

Premature or full-term neonates, 1 week of age or less:

6 mg/kg IV daily in two divided doses.

Neonates over 1 week of age and infants:

7.5-9.0 mg/kg daily IV in three divided doses.

Children:

6.0-7.5 mg/kg daily IV in three divided doses.

The duration of treatment is usually 7-14 days.


Adverse Effect :

Ototoxicity and nephrotoxicity. All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and also cause neuromuscular blockade.


Interaction :

Vancomycin, Cephalosporin, Cyclosporine, Furosemide, Cisplatin, Amphotericin: Increases chances of ototoxicity and nephrotoxicity.
Non-Depolarising Muscle Relaxants: Enhances effect.
Neostigmine, Pyridostigmine: Antagonises effect.


07/19/2019 03:01:25 Netilmicin
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