Drug Index



Mechanism :

It inhibits essential protein synthesis in the bacterial cell required for survival. It is used in the treatment of severe gram-negative infections and also has some activity against coagulase positive staphylococci.

Indication :

• Gram negative infections

• It is also used in many creams and ointments for topical application in skin infections and as ophthalmic solution for eye infections.

Contraindications :

Hypersensitivity to gentamicin and myasthenia gravis is a contraindication to its use. Patients should be well hydrated during therapy, and renal function should be monitored. Dose adjustment is required in impaired renal function.

Dosing :


<8 days of life: 2.5 mg/kg IV/IM every 12 hours.

>8 days-2 months: 2.5 mg/kg IV/IM every 8 hours.

>2 months: 7.5 mg IV/IM once daily.

Adverse Effect :

Vestibular, auditory, nephrotoxicity and neuromuscular blockade.

Interaction :

Vancomycin, Cephalosporin, Cyclosporine, Furosemide, Cisplatin, Amphotericin: Increases chances of ototoxicity and nephrotoxicity.
Non-Depolarising Muscle Relaxants: Enhances effect.
Neostigmine, Pyridostigmine: Antagonises effect.

03/15/2020 07:13:32 Gentamicin
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0