Drug Index


Mechanism :

Piperazine acts by paralysing parasites, which allows the host body to easily remove or expel the invading organism. This action is mediated by its agonist effects upon the inhibitory GABA receptor. Its selectivity for helminths is because vertebrates only use GABA in the CNS and the helminths GABA receptor is a different isoform to the vertebrate.

Indication :

  • Enterobiasis
  • Ascariasis

Contraindications :

Liver disease, impaired renal function and epilepsy are contraindications to its use.

Dosing :

Oral: >2 years:
50-75 mg/kg PO. Repeat after 2 weeks for enterobiasis and monthly for 3 months if risk of ascariasis persists.

Adverse Effect :

In patients with neurological or renal abnormalities, nausea, vomiting, colic, diarrhoea, allergic reactions, dizziness, muscular incoordination, drowsiness has been reported.

Interaction :

Pyrantel: Antagonizes the mode of action of piperazine and therefore should not be administered concurrently.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function but avoid repeated administration

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDUnknown dialysability. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Because piperazine is partially metabolized in the liver, accumulation of piperazine may occur in patients with hepatic function impairment, with an increased incidence of side effects
03/20/2024 13:18:21 Piperazine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0