Drug Index

Diiodohydroxyquin

 
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Mechanism :

It is an anti-protozoal agent active against E. histolytica, D. fragilis and G. lamblia and is considered effective against the trophozoite and cyst forms.


Indication :

• Intestinal amoebiasis


Contraindications :

Hypersensitivity to any 8-hydroxy-quinoline or iodine-containing preparations, hepatic damage and pre-existing optic neuropathy.


Dosing :

25-50 mg/kg/day PO divided into 3 daily doses for 20 days. Not to exceed 2 g/day.


Adverse Effect :

Skin eruptions, nausea, vomiting, abdominal cramps, diarrhea, pruritus ani, fever, chills, headache, vertigo, enlargement of thyroid, optic neuritis, optic atrophy, peripheral neuropathy.


Interaction :

Thyroid Function Tests: Protein-bound serum iodine levels may be increased during treatment and therefore interfere with certain thyroid function tests. These effects may persist for as long as 6 months after discontinuation of therapy. Discontinue the drug if hypersensitivity reactions occur.


08/11/2019 21:05:20 Diiodohydroxyquin
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