Drug Index


Synonym :


Mechanism :

Arginine is classified as a semi essential amino acid.

Indication :

  • Growth hormone secretion testing/Pituitary stimulation
  • Hyperammonemia due to urea cycle defects (ASA and citrullinemia)

Contraindications :

Contraindicated in arginase deficiency.

Dosing :

Growth hormone test/Pituitary stimulation:
IV infusion:
500 mg/kg IV infusion as a single dose over 30 min; maximum dose: 30 g/dose.
Hyperammonemia due to urea cycle defects: (ASA and citrullinemia)
Oral: 100-175 mg/kg 3-4 times daily upto 700 mg/day,
IV: 600 mg once given over 90 min, IV continuous infusion 600 mg/kg/24 hours (25 mg/kg/hours).

Adverse Effect :

Nausea, vomiting, headache, flushing, numbness, hypotension, local venous irritation with IV infusion. No adverse effects when given orally.

Interaction :

Estrogen-progesterone combinations; Spironolactone (potentially fatal hyperkalemia has been reported in patients with hepatic disease).

Hepatic Dose :

No dosage adjustments are recommended.
01/28/2024 01:39:00 Arginine
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