Drug Index

Arginine

 
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Synonym :

L-Arginine

Mechanism :

Arginine is classified as a semi essential amino acid.


Indication :

• Growth hormone secretion testing/Pituitary stimulation

• Hyperammonemia due to urea cycle defects (ASA and citrullinemia)


Contraindications :

Contraindicated in arginase deficiency.


Dosing :

Growth hormone test/Pituitary stimulation:

IV infusion:

500 mg/kg IV infusion as a single dose over 30 min; maximum dose: 30 g/dose.

Hyperammonemia due to urea cycle defects: (ASA and citrullinemia)

Oral: 100-175 mg/kg 3-4 times daily upto 700 mg/day,

IV: 600 mg once given over 90 min, IV continuous infusion 600 mg/kg/24 hours (25 mg/kg/hours).


Adverse Effect :

Nausea, vomiting, headache, flushing, numbness, hypotension, local venous irritation with IV infusion. No adverse effects when given orally.


Interaction :

Estrogen-progesterone combinations; Spironolactone (potentially fatal hyperkalemia has been reported in patients with hepatic disease).


07/18/2019 02:40:59 Arginine
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