Drug Index

Benztropine Mesylate

 
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Mechanism :

Benztropine is a synthetic compound containing structural features found in atropine and diphenhydramine. Benztropine possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.


Indication :

• Drug induced dystonia

• Parkinsonism


Contraindications :

Hypersensitivity to any component of benztropine. Because of its atropine-like side effects, this drug is contraindicated in children under three years of age. Caution in patients with hypertension, tachycardia, glaucoma, genitourinary tract obstruction and tardive dyskinesia.


Dosing :

<3 years: Contraindicated because of its atropine like side effects.

>3 years of age: IM/IV/PO dose: 0.02-0.05 mg/kg IV/IM once daily or every 12 hourly.Maximum 2 mg.

Adolescents: 1-4 mg IV/IM/PO per day or every 12 hourly.


Adverse Effect :

Tachycardia, paralytic ileus, constipation, vomiting, nausea, dry mouth, toxic psychosis, including confusion, disorientation, memory impairment, visual hallucinations, exacerbation of pre-existing psychotic symptoms, nervousness, depression, listlessness, numbness of fingers, blurred vision, dilated pupils, urinary retention, dysuria.


Interaction :

Phenothiazines, Haloperidol, or other drugs with Anticholinergic or Antidopaminergic activity: Gastrointestinal complaints, fever or heat intolerance, paralytic ileus, hyperthermia and heat stroke.


07/19/2019 03:19:38 Benztropine Mesylate
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