Drug Index


Mechanism :

Being a dopamine agonist, it stimulates dopamine receptors, inhibits anterior pituitary prolactin secretion.

Indication :

  • Hyperprolactinemic states.

Contraindications :

Uncontrolled hypertension and sensitivity to any ergot alkaloids, uncontrolled hypertension.

Avoid abrupt withdrawal of the drug.

Dosing :

Orally with food
>11 years: 1.25-2.5 mg once a day initially, may increase the dose over 2-7 days by 2.5 mg/day (Dose range: 2.5-10 mg daily). Taper dose gradually until it is discontinued.

Adverse Effect :

Nausea, headache, dizziness, fatigue, light headedness, vomiting, abdominal cramps, nasal congestion, GI upset, drowsiness, cerebrospinal fluid rhinorrhea.

Interaction :

Alcohol: The risk of using Bromocriptine in combination with other drugs has not been systematically evaluated, but alcohol may potentiate the side effects of Bromocriptine.

Dopamine Antagonists, Butyrophenones, and certain other agents: Bromocriptine may interact with dopamine antagonists, butyrophenones, and certain other agents.

Phenothiazines, Haloperidol, Metoclopramide, Pimozide: Compounds in these categories result in a decreased efficacy of Bromocriptine.

Other Ergot Alkaloids: Concomitant use of Bromocriptine with other ergot alkaloids is not recommended.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Bromocriptine is metabolized by the liver. Use with caution in hepatic impairment as concentrations of bromocriptine may increase. Dose adjustment may be required.
02/22/2024 17:07:47 Bromocriptine
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