Drug Index

Pancreatin

 
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Synonyms :

Lipase, Pancreatic Lipase, Pancrelipase

Mechanism :

Pancreatin contains high levels of biologically active pancreatic enzymes (lipase, amylase, and protease). The enzymes catalyse the hydrolysis of fats into glycerol and fatty acids, proteins into proteases and derived substances, and starch into dextrins and sugars.


Indication :

• Pancreatic insufficiency causing malabsorption syndrome


Contraindications :

In patients known to be hypersensitive to pork protein and in patients with acute pancreatitis or with acute exacerbations of chronic pancreatic diseases.


Dosing :

Infants: 2000-4000 lipase units/kg/120 ml of milk. Administer prior to feeding. Capsule should not be mixed directly in milk.

Children <4 years: 1000 lipase units/kg/meal. Maximum: 2500 lipase units/kg/meal or 10,000 lipase units/kg/day.

>4 years and adults: 400-500 lipase units/kg/meal. Maximum: 2500 lipase units/kg or 10,000 lipase units/kg/day.

Adjust dose according to body weight and stool fat content. Total daily dose in children and adults is divided into 3 meals/day plus 2-3 snacks/day with half the meal time dose given with the snack.


Adverse Effect :

Nausea, vomiting, abdominal discomfort and diarrhea, allergic-type reactions, hyperuricemia, hyperuricosuria, fibrosing colonopathy, intestinal obstruction,


Interaction :

Calcium Carbonate, Magnesium Hydroxide: May decrease effectiveness of enzymes, pancreatin may decrease the response to oral iron therapy.


08/11/2019 21:03:12 Pancreatin
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