Drug Index

Buprenorphine

 
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Mechanism :

It is an opioid analgesic used in the treatment of intractable pain and cyanotic spells. It is 25 times more potent than morphine and has a longer duration of action.


Indication :

• Injection: Management of moderate to severe pain.

• Sub lingual tablets: Treatment of opioid dependence.


Contraindications :

Hypersensitivity to buprenorphine or any of its components.


Dosing :

<2 years: Safety and efficacy not established.

Management of mild to moderate pain:

2-12 years: 2-6 mcg/kg slow IV/IM every 4-6 hours.

>12 years (same as adults): 0.3 mg IV/IM every 6 hours. When given IV, administer slowly over 2 minutes; may be repeated once (up to 0.3 mg) if required 30-60 minutes after initial dose.


Adverse Effect :

Asthenia, chills, headache, infection, abdominal pain, back pain, withdrawal syndrome, dizziness, confusion, fatigue, nervousness, slurred speech, paresthesia, somnolence, tinnitus, tremor, coma, convulsions, elevated cerebrospinal fluid pressure, hypoventilation, cyanosis, constipation, diarrhea, nausea, vomiting, rash, hives, pruritus, bronchospasm, angioneurotic edema, anaphylactic shock, vasodilation, orthostatic hypotension, chest pain, sweating, blurred vision, conjunctivitis, amblyopia, and miosis, euphoria, depersonalization, depression, dreaming, psychosis, auditory and visual hallucinations, urinary retention.


Interaction :

CNS depressants: Increased CNS depression may occur in patients receiving concurrent CNS depressants (e.g., narcotic analgesics, general anesthetics, benzodiazepines, phenothiazines, tranquilizers, sedative/hypnotics, or alcohol)

Diazepam: Respiratory and cardiovascular collapse with concurrent use of diazepam.

Alvimopan: Increases levels of buprenorphine by receptor binding competition and its concurrent use is contraindicated.


07/14/2019 20:35:18 Buprenorphine
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