Drug Index

Diazepam

 
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Mechanism :

Diazepam is a benzodiazepine. Benzodiazepines presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system. All benzodiazepines cause a dose-related central nervous system depressant activity.


Indication :

• Status epilepticus

• Sedation (for procedures)

• Muscle Spasms


Contraindications :

Respiratory depression, especially seen with coexistent respiratory disease or myasthenia gravis; There is potential for growing dependence, therefore only short-term use is recommended; Acute porphyria.


Dosing :

Sedative/Muscle Relaxant:

Under 6 years: Not recommended.

Above 12 years: 0.12 mg/kg/day orally in 3-4 divided doses OR 0.04-0.2 mg/kg intravenous/intramuscular every 2-4 hours; Max: 0.6 mg/kg every 8 hours.

Status Epilepticus:

Per rectal:

2-6 years: 0.5 mg/kg, repeat after 4-12 hours as per requirement.

6-12 years: 0.3 mg/kg, repeat after 4-12 hours as per requirement.

Above 12 years: 0.2 mg/kg, repeat after 4-12 hours as per requirement.

Intravenous:

6 months-5 years: 0.2-0.5 mg intravenously, can be repeated every 2-5 minutes;

Max: 5 mg. Can be repeated 2-4 hours later as per requirement.

Above 5 years: 1 mg slow intravenous infusion every 2-5 minutes;

Max: 10 mg: can be repeated after 2-4 hours if needed.


Adverse Effect :

Drowsiness, fatigue, ataxia, venous thrombosis and phlebitis at the site of injection, confusion, depression, dysarthria, headache, hypoactivity, slurred speech, syncope, tremor, vertigo, bradycardia, cardiovascular collapse, hypotension, blurred vision, diplopia, nystagmus, urticaria, skin rash, hiccups, changes in salivation, neutropenia, jaundice.


Interaction :

CNS depressants: Caution with other CNS depressants.


07/19/2019 04:10:07 Diazepam
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