Drug Index

Caspofungin

 
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Mechanism :

Caspofungin acetate inhibits the synthesis of b (1,3)-D-glucan, an essential component of the cell wall of susceptible Aspergillus species and Candida species. b (1,3)-D-glucan is not present in mammalian cells. Caspofungin has shown activity against Candida species and in regions of active cell growth of the hyphae of Aspergillus fumigatus.


Indication :

• Treatment of candidemia and invasive candidiasis.

• Treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies.


Contraindications :

Caspofungin is contraindicated in patients with hypersensitivity to any component of this product.


Dosing :

>3 months: Loading dose: 70 mg/sqm/day on day 1, max 70 mg, followed by 50 mg/sqm/day, Max: 50 mg OD.

Duration of treatment should be based on the patients clinical response.


Adverse Effect :

Histamine-mediated symptoms of rash, facial swelling, pruritus, sensation of warmth, or bronchospasm, anaphylaxis.


Interaction :

For patients receiving both therapies, standard monitoring of tacrolimus blood concentrations and appropriate tacrolimus dosage adjustments are recommended.
Cyclosporine (one 4 mg/kg dose or two 3 mg/kg doses): Increased the AUC of caspofungin by approximately 35% There were transient increases in liver ALT and AST when co-administered.
Rifampin: A drug-drug interaction study with rifampin in healthy volunteers has shown a 30% decrease in caspofungin trough concentrations.
Inducers of drug clearance: Co-administration of other inducers of drug clearance (efavirenz, nevirapine, phenytoin, dexamethasone, or carbamazepine) may result in clinically meaningful reductions in caspofungin concentrations. Use of a daily dose of 70 mg should be considered.


07/18/2019 11:55:01 Caspofungin
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