Drug Index

Domperidone

 
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Mechanism :

Domperidone is an antidopaminergic drug, and is used orally, rectally or intravenously to suppress nausea and vomiting. It has also been used to stimulate lactation.


Indication :

• Vomiting

• Gastroesophageal reflux disease (GERD)


Contraindications :

Contraindicated in patients with known hypersensitivity to domperidone, in the presence of gastro-intestinal haemorrhage, obstruction or perforation and in patients with a prolactin-releasing pituitary tumour. Prolonged QT-intervals have been seen in neonates.


Dosing :

1 month-12 years: 200-400 microgram/kg/dose 3-4 times a day before food.

12-18 years: 10-20 mg 3-4 times a day.


Adverse Effect :

Dystonic reactions, reversible raised serum prolactin levels that may lead to galactorrhoea and gynaecomastia, hypertensive crises in patients with pheochromocytoma, urticaria and abdominal cramps.


Interaction :

Anti-cholinergic drugs: May inhibit the anti-dyspeptic effects.
Anti-muscarinic agents and opioid analgesics: May antagonise the effect.
May enhance the absorption of concurrently administered drugs.


07/17/2019 10:38:05 Domperidone
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