Drug Index

Flavoxate

 
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Mechanism :

Flavoxate acts as a direct antagonist at muscarinic acetylcholine receptors in cholinergically innervated organs. Its anticholinergic-parasympatholytic action reduces the tonus of smooth muscle in the bladder, effectively reducing the number of required voids, urge incontinence episodes, urge severity and improving retention, facilitating increased volume per void.


Indication :

• Increased urinary frequency, dysuria


Contraindications :

Obstructive uropathy, pyloric/duodenal obstruction, ileus, GI bleeding, achalasia.


Dosing :

Under 12 years: Safety and efficacy not established hence not recommended.

Above 12 years: 100 to 200 mg orally 3 to 4 times daily. As symptoms improve dose may be reduced.


Adverse Effect :

Nausea, vomiting, dry mouth, tachycardia, palpitation, vertigo, mental confusion, headache, drowsiness, nervousness, urticaria, eosinophilia, hyperpyrexia, leukopenia, increased ocular tension, blurred vision, disturbance in eye accommodation.


Interaction :

Pramlintide: This drug should not be used with the following medication because a very serious interaction may occur.
Tacrine: The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Flavoxate, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide, Triprolidine, Trospium and Flavoxate: May cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.


07/14/2019 19:37:12 Flavoxate
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