Drug Index

Halofantrine

 
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Mechanism :

Halofantrine, a phenanthrene methanol, is a blood schizonticide that is active against all malaria parasites. It is active against P. falciparum infections that are resistant to chloroquine and to sulfa drug-pyrimethamine combinations.


Indication :

• Malaria, especially as a part of artemisinin combination therapy (ACT).


Contraindications :

The use of halofantrine is contraindicated in persons with a history of allergy to the drug, with pre-existing cardiac disease, with a family history of sudden death or of congenital prolongation of the QTc interval, who are using other drugs or have a clinical condition known to prolong the QTc interval, who have received treatment with mefloquine in the previous 3 weeks, pregnant women, breastfeeding mothers and children under one year.


Dosing :

Not recommended in children of <10 kg as data is insufficient.

>10 kg: 8 mg/kg/day PO in 3 divided doses every six hours.


Adverse Effect :

Diarrhea, abdominal pain, vomiting, headache, pruritus, elevated liver enzymes, rash, myalgia, back pain, rigors, QT prolongation.


Interaction :

Not known.


07/21/2019 22:03:24 Halofantrine
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